The E4 (epsilon 4) form of the APOE gene has been associated with disorders of lipid metabolism (increased plasma cholesterol and triglyceride levels) and increased susceptibility to cardiovascular disease and neurodegenerative conditions such Alzheimer’s disease.
All of us have a 1 in 2 lifetime risk of cancer, but some common cancers – breast, melanoma, pancreatic, prostate and ovarian – are known to occur more frequently in families, passing from one generation to the next.
The CardioGenomic Plus™ Profile uses genomic testing to identify the risk of genetic susceptibility to cardiac related diseases and conditions. This test evaluates genetic variations, called single nucleotide polymorphisms (SNPs) in genes that modulate blood pressure regulation, lipid balance, nutrient metabolism, inflammation, and oxidative stress.
£ 800.00(-25.00%) £ 600.00
The impact of diet, lifestyle, exercise, and environment on an individual’s genetic makeup should not be underestimated. Knowledge of how genes are influenced by external factors enables the development of personalised health programs not only in supporting the chronically ill patient to improve health, but also for someone at peak fitness levels to gain the most from their training programs.
Our DNA tests focus on health management, dietary disposition, athletic performance and drug metabolism. Each test provides a unique insight into a patient’s genetic code: revealing sensitivities, susceptibilities, and keys to their true health potential.
Our Comprehensive Genetic Profile Tests Package includes:
DNA Health, DNA Diet, DNA Oestrogen and DNA Mind.
The Detoxification report focuses on the key genes and variants involved in regulating Phase I, II and III liver detoxification pathways including those involved in the metabolism of caffeine, alcohol, hormones, neurotransmitters, pesticides and various common pharmaceutical drugs.
This test evaluates SNPs associated with increased risk of impaired detoxification capacity especially when exposed to environmental toxins. It also identifies individuals potentially susceptible to adverse drug reactions.
Test Type: Buccal Swab
One of the first products of its kind in the world, DNA Diet tests for 15 genes that impact metabolism and exercise. The genes comprising the DNA Diet test have associations with body weight and body mass index, and all meet stringent criteria for utility in genetic screening tests. We provide a detailed report with recommendations that include dietary changes and an exercise programme.
Genes involved in regulation of energy expenditure, appetite, and fat metabolism, all play an important role in weight regulation. In fact 40% to 80% of the variance in body weight is due to genetic factors. This helps to explain why not everyone gains or loses weight while following the same diet, despite being exposed to similar environments. Identifying an individual’s responsiveness to diet and lifestyle modification to control weight can be extremely advantageous.
Genetics determines an individual’s susceptibility to obesity when exposed to an unfavourable environment. It also explores the way a person responds to diet and exercise.
The DNA Health test is designed to optimise well-being and health by personalising lifestyle and diet choices and, where necessary, using supplements tailored to offset any particular nutritional deficit based on specific gene variants.
Diet is a key factor in determining genomic stability as it impacts on all relevant pathways: exposure to dietary carcinogens, biotransformation, DNA repair and synthesis, and apoptosis.
The DNA mind test analyses 30 genes which have been shown to have significant associations with key mental health disorders.
DNA mind reports on associations in the following areas:
- Neurodegenerative disorders – mild cognitive decline & late onset Alzheimer’s disease
- Mood disorders – Depressive disorder, bipolar disorder, anxiety disorder & post-traumatic stressdisorder
- Addictive behaviour – Risk for alcohol, nicotine, cannabis & opioid dependence, psychosisresponse from cannabis use, eating disorders (binge eating), ‘adrenaline seeking’/risk-taking behaviour
DNA Oestrogen includes 11 genes involved in oestrogen biosynthesis, oestrogen metabolism, and phase I and phase II detoxification, providing information to guide personalised diet, lifestyle, hormone, and nutra-ceutical recommendations.
Approximately 80% of breast cancer occurs in women with no family history. Oestrogen affects the function of a number of target tissues and research has shown that an increased lifetime exposure to oestrogen is a strong risk factor in the development of breast cancer. DNA Oestrogen tests for gene variants that have been shown to have an impact on how oestrogen is metabolised.
Guiding the personalisation of diet, hormone and nutritional supplement recommendations, based on the insight gained from the DNA Oestrogen test, to improve oestrogen metabolism is of benefit to men and women who suffer from numerous oestrogen-dominant conditions and who have higher lifetime exposure to oestrogens, oestrogen metabolites and other carcinogens.
Based on the results from the DNA Skin test, personalised lifestyle, nutrition, nutraceutical and cosmeceutical recommendations can be given for improved skin care and to decrease the visible signs of ageing.
With DNA Sport, we can help personalise a training strategy that optimises your genetic potential, and identify the right lifestyle, nutrition and environmental interactions to optimally express your genetic potential.
£ 1,200.00(-41.75%) £ 699.00
This package includes the following six DNA reports: Methylation, Detoxification, Oestrogen Balance, Histamine Intolerance, Nervous System, APOE Plus
The EstroGenomic® Profile uses genomic testing to identify susceptibility to diseases and conditions such as breast cancer, osteoporosis, and heart disease. This profile evaluates genetic variations, called single nucleotide polymorphisms (SNPs) in genes that modulate estrogen metabolism, coagulation, cardiovascular function, bone health, and inflammation.
£ 1,200.00(-25.00%) £ 900.00
The human genome is comprised of approximately 3 billion base pairs of DNA. Many people mistakenly assume that the presence of a certain gene or single nucleotide polymorphism (SNP) means they are destined to experience the associated disease. However, most genes have flexible expressions and complex interactions among multiple genes and the environment affect gene expression.
These interactions – known as epigenetic influences – include diet, chemical exposure, stress response, and the presence of other SNPs.
Our Genomics Profile Package includes:
CardioGenomicPlus Profile, DetoxiGenomic Profile, Estrogenomic Profile, ImmunoGenomic Profile, NeuroGenomic Profile
Histamine intolerance is a toxic response by the body resulting from an imbalance between accumulated histamine and the capacity to break it down.
Histamine toxicity is associated with numerous symptoms that mimic an allergic reaction such as skin irritation, gastro-intestinal upset, respiratory distress, headaches, insomnia and anxiety.
This test evaluates genetic variations in genes that modulate immune and inflammatory activity. These variations can affect balance between cell (Th-1) and humoral (Th-2) immunity, trigger potential defects in immune system defense, and stimulate mechanisms underlying chronic, overactive inflammatory responses.
Methylation is critical for keeping your body and brain biochemistry in balance.
Common genetic variants (SNPs) can impact our natural ability to methylate and thus result in increased susceptibility to systemic imbalances and chronic health conditions including heart disease, depression, diabetes, chronic fatigue, autoimmune disease, poor foetal development and premature ageing.
The nervous system DNA test examines the key genes and variants (SNPs) that affect neurotransmitter balance, nerve cell growth & maintenance, thyroid hormone conversion, inflammation and pharmacological response.
Common genetic variants combined with environmental factors including nutrient imbalances, low physical activity, toxins and other stressors can result in anxiety, depression, mood imbalances, lack of motivation, drive or focus, addiction, poor memory or sleep disturbances.
This test evaluates single nucleotide polymorphisms (SNPs) in genes that modulate methylation, glutathione conjugation, oxidative protection and the potential to evaluate vascular oxidation.
Imbalanced hormones can have a number of negative effects on health and well-being and are highly influenced by environmental, dietary and genetic factors.
The main role of oestrogen in the body is to increase the growth and production of cells, but it is also involved in the regulation of the female reproductive system, the development of secondary sex characteristics, maintenance of bone density, blood clotting, skin health and mucous membranes.