COVID 19 - A Functional Medicine Approach
Here we look at : Mechanism of action of SARS-COV-2 , Virus - Specific Nutraceutical and Botanocal Agents , Lifestyle Practices for strengthening host defense, and COVID 19 Testing available.
Mechanism of action of SARS-COV-2
A coronavirus such as SARS-CoV-2 can be deadly because of its ability to stimulate a part of the innate immune response called the inflammasome, which can cause uncontrolled release of pro-inflammatory cytokines, leading to cytokine storm and severe, sometimes irreversible, damage to respiratory epithelium.
The SARS-CoV-2 virus has been shown to activate the NLRP3inflammasome.
A 2016 review article entitled “Natural compounds as regulators of NLRP3 inflammasome-mediated IL-beta production” notes that “resveratrol, curcumin, EGCG [epigallocatechin gallate], and quercetin are potent inhibitors of NLRP3 inflammasome-mediated IL-1beta production, typically acting at more than one element of the involved pathways. However, it should be noted that these polyphenols have an even much broader biological effect, as they influence a variety of pathways.” For example, these polyphenols modulate NF-kB upregulation, which is useful to counteract the COVID-19’hyper-inflammation.
Virus Specific Nutraceutical & Botanical Agents
Food and Nutrition has a profound effect on our Immune system. The Nutraceuticals help to prevent activation of NLRP3 inflammasome, to decrease NF-kB activation, and to potentially inhbit COVID-19 replication. Brightly coloured vegetables and fruits really boosts immunity.
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Covid - 19 Diagnostic Testing
When a communicable disease outbreak begins, the ideal response is for public health officials to begin testing for it early.
That leads to quick identification of cases, quick treatment for those people and immediate isolation to prevent spread. Early testing also helps to identify anyone who came into contact with infected people so they too can be quickly treated.
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Lifestyle Practices for strenghtening Host Defences
During a time of heightened potential infection from COVID-19, favorably modulating immune function can be an important strategy for not only reducing the chance of infection, but for potentially reducing the severity of and sequelae from infections. Since lifestyle factors have a large effect on immune function, when working with patients in the era of COVID-19, the modifiable lifestyle factors below are excellent first steps.
At this time, there are no specific vaccines or uniformly successful treatments for COVID-19. In this context of insufficient evidence, the scope of information provided is limited to scientific plausibility of promising prevention approaches and therapeutic (nutraceutical and botanical) interventions rather then to offer clinical recommendations. Strengtening the Host defense system may render the host to deal with the virus efficently, reduce severity and improve recovery of Coronavirus related infection.